Performance-based conditions generally include the attainment of goals related to its financial performance and product development. To the extent that the company raise additional funds through collaboration and licensing arrangements, it may be necessary to relinquish some rights to its technologies or its product candidates or grant licenses on terms that may not be favorable to it. The decrease in cash provided by investing activities for the three months ended March 31, 2018 as compared to the same period of 2017 is primarily due to the net effect from purchases, sales, and maturities of marketable securities. HOPE-2 will measure the change from the beginning of the trial, or baseline, to Month 12. The company had cash flow provided by financing activities of approximately $2.5 million and zero for the three months ended March 31, 2018 and 2017, respectively. CSps are a 3D micro-tissue from which CDCs are derived, and have shown significant healing effects in pre-clinical models of heart failure. In June 2016, Capricor reported positive 12-month data from the DYNAMIC study. In May 2013, Kite Pharma completed a $35 million financing of. The study was sponsored and conducted by CSMC in collaboration with JHU. Accordingly, its success depends not only on the safety and efficacy of its product candidates, but also on its ability to finance the development of the products and its clinical programs. The company's estimates regarding the sufficiency of its financial resources are based on assumptions that may prove to be wrong. Adult stem cells maintain and repair tissues throughout life. The company was founded in 2005 in. As of March 31, 2018, the Company’s liability balance for the CIRM Award was $3.4 million, of which approximately $0.6 million is recorded as restricted cash, due to the fact that Capricor is required to expend approved project costs in order to use these funds. Twenty-five patients were randomized in a 1:1 ratio to receive either CAP-1002 on top of usual care or usual care only. The analyst consensus points to a rating of ‘Buy’. The information on this Website is not reliable and not intended to provide tax, legal, or investment advice. The second trial is known as “Pulmonary Arterial Hypertension treated with Cardiosphere-derived Allogeneic Stem Cells.” In both studies, Capricor will provide the necessary number of doses of cells and will receive a negotiated amount of monetary compensation which is estimated to be approximately $2.1 million over several years. If Capricor elects to convert the CIRM Award into a loan, certain requirements of the CIRM Award will no longer be applicable, including the revenue sharing requirements. Capricor is developing its exosome technologies as a next generation platform in a variety of diseases. The March 2017 ATM Program became fully utilized in October 2017. Research and development, or R&D, expenses consist primarily of salaries and related personnel costs, supplies, clinical trial costs, patient treatment costs, rent for laboratories and manufacturing facilities, consulting fees, costs of personnel and supplies for manufacturing, costs of service providers for pre-clinical, clinical and manufacturing, and certain legal expenses resulting from intellectual property prosecution, stock compensation expense and other expenses relating to the design, development, testing and enhancement of its product candidates. To receive the RMAT designation, the company submitted data from the HOPE-Duchenne Trial. Cell Design Labs (acquired by Gilead Sciences ) - private biotherapeutics company pioneering breakthrough science to develop disruptive cell-based therapies for cancer and other devastating diseases. Devgen is a Belgium-based multinational agricultural biotechnology company.It uses biotechnology and molecular breeding technologies to develop varieties of food crops.Its technology is marketed by outlicensing or selling seeds in India and South-East Asia. Exosomes are a cell-free substance and may be stored, handled, reconstituted, and administered in similar fashion to common biopharmaceutical products such as antibodies. Arno Therapeutics - clinical-stage biopharmaceutical company that is developing products for the treatment of cancer. Capricor Therapeutics, Inc. operates as a clinical stage biotechnology company. To date, most of its development expenses have related to its product candidates, consisting of CAP-1002, CAP-2003 and its former product candidate, Cenderitide. On November 17, 2017, the company gave notice to CIRM that the company were electing to abandon the CIRM-funded project pursuant to the Loan Agreement and on December 11, 2017, Capricor and CIRM entered into Amendment No. In comparison, the usual care group showed a mean 8.8% (27.7%) decrease at six months and a mean 1.6% (37.9%) increase at 12 months in the systolic thickening of the inferior wall. Of the five NYHA Class III subjects who received the highest dose of CAP-1002 (75 million cells), two subjects improved by two Classes (to Class I) and three improved by one Class (to Class II) at six months. The company has developed an allogenic .css-1n63hu8{box-sizing:border-box;margin:0;min-width:0;display:inline;}cell therapy that is meant to treat .css-1n63hu8{box-sizing:border-box;margin:0;min-width:0;display:inline;}Duchenne muscular dystrophy as well as .css-1n63hu8{box-sizing:border-box;margin:0;min-width:0;display:inline;}COVID-19. While there are many clinical initiatives in DMD, HOPE-2 is one of the very few to focus on non-ambulant patients. CAP-1001 (autologous CDCs) was the subject of the CSMC and JHU-sponsored Phase I CADUCEUS trial and is not in active development. Sienna Biopharmaceuticals - discovery, clinical development and commercialization of products in dermatology and aesthetics. Our studies have been showing that our exosome technology is significantly active in several disease models. 3 whereby the total loan balance and all accrued interest under the CIRM Loan Agreement has been forgiven by CIRM thereby terminating Capricor and the Company’s obligation to repay the loan balance. Article by: Amilia Stone The Company classified the forgiveness of the loan payable, consisting of principal and accrued interest, of approximately $15.7 million as “other income” in its Consolidated Statement of Operations and Comprehensive Income (Loss) for the period ending December 31, 2017. 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